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2 572 575

(13)

(51)

IPC

C07K7/00(2006-01-01)

A61K47/42(2006-01-01)

A61K47/48(2006-01-01)

(21) (22)

Application

2014144069/10, 2014-10-31

(24)

Start date

2014-10-31

(22)

Actual filing date

2014-10-31

(45)

Published

2016-01-20

(72)

Inventor

Andreev Sergej MikhajlovichChupina Nina Anatol'EvnaShilovskij Igor' PetrovichKhaitov Musa Rakhimovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauchnyj Tsentr Immunologii" Federal'Nogo Mediko-Biologicheskogo Agentstva Rossii Institut Immunologii" Fmba Rossii)

MEAN FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS TO CELLS OF MAMMALS Russian patent published in 2016 - IPC C07K7/00 A61K47/42 A61K47/48

Abstract RU 2572575 C1

FIELD: bioengineering.

SUBSTANCE: invention relates to creation of low-toxic cation dendrimer peptide with structural formula (Arg)₈(Lys)₄(Lys)₂LysAlaCys-NH₂(Fig. 1). The said dendrimer peptide is used as the mean for intracellular delivery of nucleic acids to cells of mammals. At ratio of number of positive charges to number of negative phosphate groups of the nucleic acids from 24 to 96 the dendrimer peptide can effectively penetrate in different types of cells of the mammals and completely interact with the plasmid DNA. At LD₅₀ for 0.8-1.5 mg/ml the mean for intracellular delivery of nucleic acids to cells of mammals is low toxic.

EFFECT: higher efficiency of the mean.

2 cl, 12 dwg, 3 tbl, 4 ex

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RU 2 572 575 C1

Authors

Andreev Sergej Mikhajlovich

Chupina Nina Anatol'Evna

Shilovskij Igor' Petrovich

Khaitov Musa Rakhimovich

Dates

2016-01-20—Published

2014-10-31—Filed