FIELD: genetic engineering and biochemistry.
SUBSTANCE: invention relates to the field of genetic engineering and biochemistry, as well as to medicine and pharmaceuticals, and is aimed at creating low-toxic cationic dendrimeric peptides as intracellular transporters of nucleic acids (NA) of various structures. A means for intracellular delivery of nucleic acids into mammalian cells is proposed, which is a dendrimeric cationic peptide.
EFFECT: resulting agent provides delivery of both plasmid DNA and small interfering RNA (siRNA), which makes it possible to use it as a promising agent for gene therapy, including therapy based on RNA interference.
1 cl, 15 dwg, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MEAN FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS TO CELLS OF MAMMALS | 2014 |
|
RU2572575C1 |
| LABELLED DENDRIMER PEPTIDES | 2016 |
|
RU2611399C1 |
| COMBINED DRUG WITH ANTIVIRAL EFFECT AGAINST NEW SARS-COV-2 CORONAVIRUS | 2021 |
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RU2746362C1 |
| COMPOSITION FOR INTERLEUKINE-4 CYTOKINE GENE SILENCING | 2014 |
|
RU2563989C1 |
| COMPOSITION INHIBITING EXPRESSION OF INTERLEUKIN-4 AND INTERLEUKIN-13 GENES FOR THERAPY OF ALLERGIC RHINITIS | 2018 |
|
RU2710895C1 |
| CATIONIC BRANCHED PEPTIDE FOR RESPIRATORY VIRUS INHIBITION | 2022 |
|
RU2810986C2 |
| METHOD FOR PRODUCTION OF AMPHIPHILIC BLOCK COPOLYMERS N, N-DIMETHYLAMINOETHYL METHACRYLATE FOR NUCLEIC ACID DELIVERY TO LIVING CELLS | 2014 |
|
RU2617059C2 |
| AGENT FOR INHIBITION OF REPLICATION OF SARS-COV-2 VIRUS MEDIATED BY RNA INTERFERENCE | 2020 |
|
RU2733361C1 |
| MOLECULAR CONJUGATE ON BASIS OF SYNTHETIC ANALOGUES OF LULIBERIN AND APPLICATION THEREOF AS DNA DELIVERY SYSTEM TO CELLS OF HORMONE-SENSITIVE TUMOURS (VERSIONS) | 2007 |
|
RU2377247C2 |
| APPLICATION OF CATIONIC PEPTIDES FOR HUMAN MELANOMA CELLS DEATH INDUCTION | 2016 |
|
RU2620170C1 |
