FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biotechnology, genetic engineering and virology. Particles are similar to with flu virus particles. Method includes expression of chimeric HA virus of flu in plant or in the part of plant. Claimed invention also relates to VLP, which includes chimeric protein of HA virus of flu or plant lipid. Invention also relates to nucleic acid, which codes chimeric Ha virus of flue, and vector. VLP can be applied for preparation of vaccines against flu or for improvement of existing vaccines. Claimed group of inventions can be applied in medicine.
EFFECT: claimed is method of obtaining chimeric virus-like particles (VLP) in plant or in its part.
37 cl, 60 dwg, 5 tbl, 5 ex
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