METHOD OF PRODUCING METRONIDAZOLE Russian patent published in 2014 - IPC C07D233/94 

Abstract RU 2531616 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing metronidazole by alkylating 2-methyl-4(5)-nitroimidazole with ethylene chlorohydrin while heating in the presence of hydrochloric acid, removing excess alkylating agent at low pressure and filtering off unreacted 2-methyl-4(5)-nitroimidazole, after which the obtained solution is neutralised, cooled and filtered and the separated product is purified.

EFFECT: novel method of producing metronidazole, characterised by high output of the end product.

4 cl, 1 ex

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RU 2 531 616 C1

Authors

Selikhova Natal'Ja Jur'Evna

Odnokopylova Margarita Viktorovna

Mal'Kov Viktor Sergeevich

Dates

2014-10-27Published

2013-03-29Filed