FIELD: chemistry.
SUBSTANCE: invention relates to a method of obtaining a polymer conjugate of an indolocarbazole compound of formula 
(I), where R1, R2, R3, W1 and W2 represent hydrogen, X represents methoxy-polyethyleneglycol. The method includes the interaction of a polymer compound of formula (II) 
with an indolocarbazole compound of formula 
(III), where Y stands for a methoxygroup. The nvention also relates to a polymer conjugate of formula (I), a pharmaceutical composition, containing the conjugate of formula (I) as an active ingredient, and to the application of the polymer conjugate of formula (I).
EFFECT: obtaining the polymer conjugate of the formula with a high output, the polymer conjugate of the formula for treatment of skin pathologies and HMGB1-associated pathologies.
48 cl, 7 dwg, 7 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEGYLATED COMPOUNDS OF RECOMBINANT HUMAN GROWTH HORMONE | 2009 |
|
RU2530714C9 |
| PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING GROWTH HORMONE-ASSOCIATED DISEASES IN HUMANS | 2014 |
|
RU2689336C2 |
| PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT OF GROWTH HORMONE-RELATED DISEASES IN HUMANS | 2019 |
|
RU2802215C2 |
| ENZYMATIC ANTICANCER THERAPY | 2008 |
|
RU2481855C2 |
| NANOPARTICLES FOR ENCAPSULATING COMPOUNDS, PRODUCTION AND USE THEREOF | 2015 |
|
RU2718922C2 |
| STABLE RECOMBINANT ADENOSINE DEAMINASE | 2008 |
|
RU2486246C2 |
| COMPOSITION COMPRISING A GLP-1 RECEPTOR AGONIST AND A GLUCAGON RECEPTOR AGONIST, AND USE THEREOF | 2016 |
|
RU2719144C2 |
| POLYETHYLENE GLYCOL DERIVATIVE OF NEUROTROPHIC FACTOR POLYPEPTIDE AND METHOD OF PREPARATION THEREOF | 1995 |
|
RU2136694C1 |
| PEG-MODIFIED EXENDIN OR EXENDIN ANALOGUE AND ITS COMPOSITIONS AND USE | 2007 |
|
RU2498814C2 |
| PRODRUGS CONTAINING INSULIN LINKER CONJUGATE | 2010 |
|
RU2574667C2 |
