FIELD: biochemical syntheses. SUBSTANCE: compound is prepared by interaction of polypeptide selected from growth factor isolated from brain and neurotrophin-3 with polyethylene glycol under reductive alkylation conditions at acidic pH. Homogeneous conjugate molecules thus prepared bears directly attached polyethylene glycol residues. EFFECT: facilitated synthetic procedure. 14 cl, 8 dwg, 2 tbl, 11 ex
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Authors
Dates
1999-09-10—Published
1995-11-13—Filed