METHOD OF OBTAINING COMPOUNDS, REPRESENTING DERIVATIVES OF KETOMALONIC ACID, OR THEIR HYDRATES Russian patent published in 2014 - IPC C07C67/31 C07C67/313 C07C69/675 C07C69/716 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining a compound, representing a derivative of ketomalonic acid, represented by the following general formula (2) , in which R¹ can be similar or different from each other and represent a hydrogen atom, normal or branched C₁-C₆ alkyl group, cyclic C₃-C₆ alkyl group, aryl group or a heteroaryl group; where the normal or branched C₁-C₆ alkyl group and cyclic C₃-C₆ alkyl group can have a substituent, selected from the group, consisting of the normal or branched C₁-C₆ alkyl group, cyclic C₃-C₆ alkyl group, hydroxyl group, normal or branched C₁-C₆ alkoxygroup, aryl group or a heteroaryl group; and the aryl group and the heteroaryl group can have a substituent, selected from the group, consisting of the normal or branched C₁-C₆ alkyl group, cyclic C₃-C₆ alkyl group, hydroxyl group, normal or branched C₁-C₆ alkoxygroup, aryl group, heteroaryl group and a halogen; or its hydrate by the interaction of the compound, representing the derivative of malonic acid, represented by the following general formula (1) , in which R¹ is the same as described above, or its mixture with one or two or more compounds of chlorous acid, selected from the group, consisting of chlorous acid or a salt of chlorous acid, for the oxidation of the compound, representing the malonic acid derivative.

EFFECT: claimed method does not require highly toxic reagents, dangerous reagents, special reagents, special equipment for the reaction, expensive reagents, expensive catalysts or transition metals, such as noble metals, and makes it possible to select mild reaction conditions and provides an easy exploitation, thus making it possible to effectively and easily obtain compounds, representing derivatives of ketomalonic acid, such as ketomalonic diethers, in simple and easily obtainable conditions, suitable for the introduction into the industrial production.

24 cl, 13 ex, 1 tbl