FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of quinoline of the general formula (I) where Y means group C-G where G - carboxy- or alkoxycarbonyl-group; - imidazole, benzimidazole, pyrazole, triazole, 1,2-dihydropyridine, indolyl optionally substituted with alkyl, amino-, hydroxy-, oxo- or formyl-group; each of A and B rings can be substituted with 1-3 substituents taken from halogen atom, hydroxy-, oxo-, alkyl-, alxoxy-group and -O(CH2)l-group; l - the whole number 1-3; n - the whole number 1-4; k = 0 or 1, or their pharmaceutically acceptable salts showing an anti-inflammatory effect. EFFECT: improved method of synthesis, an anti-inflammatory activity of compounds. 21 cl, 10 tbl, 63 ex
Title |
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