AMINOPYRAZINE DERIVATIVES AND MEDICATIONS Russian patent published in 2014 - IPC C07D401/14 C07D401/12 C07D403/12 C07D403/14 C07D417/14 C07D491/113 C07D413/14 A61K31/497 A61K31/506 A61K31/551 A61K31/541 A61K31/438 A61P35/00 A61P35/02 A61P7/02 A61P9/10 A61P9/14 A61P19/10 A61P19/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of general formula [1] or their pharmaceutically acceptable salts, which possess properties of an inhibitor of the JAK2 thyrokinase activity. In general formula radicals are selected from group (I) or (II). In group (I) X represents CH or N; R¹ represents a halogen atom and R² represents H, a halogen atom, CN, or is selected from the groups of formulas

,

or a group -OR^P or 5-6-membered heteroaryl, containing 1-4 nitrogen atoms and optionally additionally containing an oxygen or sulphur atom or containing an oxygen atom as a heteroatom, optionally substituted; or (II) X represents -CR^A; and R^A represents a group of formula , R^B represents (a) amino, optionally substituted with one or two groups, selected from the group, consisting of C1-6alkyl, C3-6cycloalkyl, (C3-6cycloalkyl)C1-6alkyl and C1-3alcoxyC1-3alkyl, (b) C1-3alcoxy, (c) hydroxy or (d) a 5-6-membered saturated cyclic amino group, which additionally can contain a heteroatom, selected from an oxygen atom; R¹ represents a halogen atom and R² represents H; R³ -R⁵ have values given above. Other values of the radicals are given in the invention formula.

EFFECT: compounds can be applied for the prevention or treatment of cancer, for instance hematologic cancer disease or a solid form of cancer, inflammatory disorder, for instance, rheumatoid arthritis, inflammatory intestinal disease, osteoporosis or multiple sclerosis and angiopathy, for instance, pulmonary hypertension, arteriosclerosis, aneurism or varicose veins.

14 cl, 19 tbl, 234 ex