FIELD: biotechnologies.
SUBSTANCE: biologically active material, a matrix shaping agent and at least two glass-shaping agents are combined in a water solvent so that a viscous suspension is obtained. The obtained suspension is quickly frozen in liquid nitrogen with formation of solid frozen particles in the form of granules, drop particles or fibres. Frozen particles are degassed under vacuum gauge pressure of 0 to 2000 mTorr (266.6 Pa) and at the temperature below a composition freezing point during 1-30 minutes. Further, particles are subject to primary drying at the pressure of 2000 to 10000 mTorr (266.6 to 1333 Pa) and at the temperature above the particle freezing point. Secondary drying of particles is performed at full vacuum and temperature of 20°C to 70°C during the period of the time sufficient for reduction of activity of water of the obtained composition to Aw 0.3 or below.
EFFECT: excluding boiling or excess foaming of a composition at simultaneous achievement of considerable acceleration of drying and high allowable load of the composition.
11 cl, 9 dwg, 1 tbl, 16 ex
