METHOD OF OBTAINING 3-ALKYLDIHYDROFURAN--2(3H)-ONES Russian patent published in 2015 - IPC C07D307/33 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining 3-alkyldihydrofuran--2(3H)-ones of formula where R=n-C₄H₉,n-C₅H₁₂,n-C₆H₁₃ , which is realised by the interaction of N,N-dimethylalk-2-in-1-amines with triethylaluminium in the presence of the catalyst zirconacendichloride (Cp₂ZrCl₂) in an inert atmosphere at a temperature of ~40°C for 4 h with further cooling of the reaction mass to -10°C, addition of borotrifluoride etherate in a double with respect to AlEt₃ amount, mixing at a temperature of ~20°C for 45 min, further addition of a 20% water solution of NaOH and a 30% solution of H₂O₂ to the cooled to 0°C reaction mass with mixing at room temperature for 24 h. Output of target products (1) constitutes 60-62%. The claimed method makes it possible to simplify the process due to the elimination of necessity to carry out the process at very low temperatures (-60°C).

EFFECT: compounds present interest as precursors and building blocks in the synthesis of natural compounds, possessing various types of biological activity, and are also known as carriers of pleasant odours and therefore are of interest for food and cosmetic industries.

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