DERIVATIVES OF 4-PHENYLPYRROLIDONE WITH ANTICONVULSANT AND NOOTROPIC ACTIVITY AS MEANS OF TREATING EPILEPSY AND PAROXYSMAL CONDITIONS Russian patent published in 2021 - IPC C07D207/27 C07D401/12 A61K31/4015 A61K31/4439 A61P25/08 

FIELD: biochemistry.

SUBSTANCE: invention relates to derivatives of (2-oxo-4-phenylpyrrolidin-1-yl) acetic acid of general formula (1), in which "n" can be equal to 0, R¹ and R⁵ can simultaneously be alkyl groups, with one or more of groups R², R³, R⁴ being hydrogen atoms, alkyl, alkoxy and trifluoromethyl groups; or «n» can be equal to 0, R¹ can be a methyl or alkoxy group, while R², R³, R⁴ and R⁵ are hydrogen atoms; or «n» can be equal to 0, with one or more of groups R¹, R², R³, R⁴, R⁵ being a trifluoromethyl one, and the rest are hydrogen; or «n» can be equal to 1, while R¹, R², R³, R⁴, R⁵ can be hydrogen. The invention also relates to a method for the preparation of (2-oxo-4-phenylpyrrolidin-1-yl) acetic acid derivatives of the general formula (1) and to their use.

EFFECT: new compounds of general formula (1) have been obtained, which can be used as anticonvulsants for prevention and treatment of paroxysmal conditions, including epilepsy.

8 cl, 6 tbl, 14 ex