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(19)

(11)

2 539 350

(13)

(51)

IPC

C07C235/60(2006-01-01)

C07C65/10(2006-01-01)

A61K31/166(2006-01-01)

A61K31/60(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2013157471/04, 2013-12-24

(24)

Start date

2013-12-24

(22)

Actual filing date

2013-12-24

(45)

Published

2015-01-20

(72)

Inventor

Perlovich German LeonidovichManin Aleksej NikolaevichManin Nikolaj Gennad'EvichVoronin Aleksandr Pavlovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimii Rastvorov Im. G.A. Krestova Rossijskoj Akademii Nauk Ran)

CO-CRYSTALLINE FORM OF 2-HYDROXYBENZAMIDE WITH SALICYLIC ACID Russian patent published in 2015 - IPC C07C235/60 C07C65/10 A61K31/166 A61K31/60 A61P29/00

Abstract RU 2539350 C1

FIELD: chemistry.

SUBSTANCE: in claimed co-crystalline form molar ratio of 2-hydroxybenzamide and salicylic acid constitutes 1:1. Co-crystalline form is characterised by peaks at 2θ(°) 11.5, 14.8, 16.7, 18.8, 22.2, 23.5, 27.0 by the data of measurement of X-ray radiation diffraction on powder, and has endothermic peak from 116 to 124°C by the data of measurement by means of differential scanning calorimetry. Claimed co-crystalline form can be applied for manufacturing pharmaceuticals.

EFFECT: increased solubility of 2-hydroxybenzamide.

7 dwg, 2 ex

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RU 2 539 350 C1

Authors

Perlovich German Leonidovich

Manin Aleksej Nikolaevich

Manin Nikolaj Gennad'Evich

Voronin Aleksandr Pavlovich

Dates

2015-01-20—Published

2013-12-24—Filed