CO-CRYSTALLINE FORM OF THEOPHYLLINE WITH DIFLUNISAL OR DICLOFENAC Russian patent published in 2015 - IPC C07D473/02 C07C65/05 C07C65/34 C07C229/42 

FIELD: medicine.

SUBSTANCE: co-crystals possess firstly the anti-inflammatory, antipyretic and analgesic action and are applicable to produce pharmaceutical preparations. The co-crystal of diflunisal and theophylline has an endothermal peak from 183 to 195°C according to the measured data by differential scanning calorimetry and peaks at 2θ(°) 5.2, 10.3, 11.9, 18.18, 23.5, 26.4 according to the measured data of X-ray powder diffraction, while the co-crystalline form of diclofenac and theophylline has an endothermal peak from 186 to 198°C according to the measured data by differential scanning calorimetry and peaks at 2θ(°) 7.6, 12.2, 16.7, 17.4, 20.1, 27.0 according to the measured data of X-ray powder diffraction. The co-crystals can be presented in the solid phase and in the solution.

EFFECT: co-crystal enables increasing water-solubility for diflunisal and for diclofenac as compared to the unformulated solubility.

12 dwg, 4 ex