CO-CRYSTALLINE FORM OF 2-HYDROXYBENZAMIDE AND 4-AMINOBENZOIC ACID Russian patent published in 2013 - IPC C07C229/60 C07C235/60 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical chemistry, more specifically to a new co-crystalline form of 2-hydroxybenzamide and 4-aminobenzoic acid. In the present co-crystalline form, the molar ratio of 2-hydroxybenzamide and 4-aminobenzoic acid makes 1: 1. The co-crystalline form is characterised by the peaks at 2θ(°) 7.53, 13.23, 17.14, 19.32, 22.76, 28.40, 32.56 according to X-ray powder diffraction, and also has an endothermic peak falling within the range of 130 to 135°C according to differential scanning calorimetry.

EFFECT: presented co-crystalline form can find application for producing pharmaceutical preparations since enables considerably increasing 2-hydroxybenzamide solubility.

3 dwg, 2 ex