METHOD OF OBTAINING BIOCOMPATIBLE GALLIUM(III)-CONTAINING HIGHLY DISPERSE PARTICLES FOR MANUFACTURING DIAGNOSTIC PREPARATIONS FOR POSITRON-EMISSION TOMOGRAPHY Russian patent published in 2015 - IPC A61K51/04 A61K51/12 A61K103/00 B82B3/00 B82Y5/00 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining biocompatible highly disperse polylactide particles for in situ manufacturing of diagnostic means for positron-emission tomography by combination of said particles with solution, containing cations of gallium 68 (III). Claimed method includes combination of solution of bidentate aromatic ligand, namely quercetin, quinalizarin, alizarin or 8-hydroxyquinoline in polar solvent with solution, containing lactic acid copolymers in low-polar solvent and intensive mixing of obtained mixture with obtaining highly homogenous mixture. After that, at least three volumes of water solution of polyvinyl alcohol with molecular weight 9.0÷80 kDa are added and intensively mixed with obtaining highly homogenous mixture. Obtained mixture is evaporated with obtaining suspension, which is filtered by filter with pore size less than 30 mcm with obtaining filtrate, with further addition of lyoprotector, freezing and lyophilisation. Invention also relates to biocompatible highly disperse particles for manufacturing radiopharmaceutical preparation for positron-emission tomography, their application for carrying out positron-emission tomography and to diagnostic composition, containing effective amount of gallium-68 (III), bound with said particles.

EFFECT: obtaining biocompatible highly dispersive polylactide particles for in situ manufacturing of diagnostic means for positron-emission tomography.

33 cl, 8 tbl, 6 dwg, 2 ex