METHOD OF OBTAINING QUINOLONE COMPOUNDS Russian patent published in 2015 - IPC C07D401/14 

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to a method of obtaining a quinolone compound, which includes a stage of interaction of a dechloroquinolone compound, or its pharmaceutically acceptable salt, or ether with a chlorinating agent and acid, in which the molar ratio of the acid to the dechloroquinolone compound constitutes from 0.008 to 0.012 and in which less than 0.40% of a dimeric admixture is obtained in a percentage of the area counted per the obtained quinolone compound, and where the quinolone compound represents 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, or its pharmaceutically acceptable salt or ether, the dechloroquinolone compound represents 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid, or its pharmaceutically acceptable salt, or ether and the dimeric admixture represents 1-amino-3-(azetidin-3-yloxy)propane-2-olbis(H,H'-quinolonecarboxylic acid) or its pharmaceutically acceptable salt or ether.

EFFECT: improved method of obtaining a quinolone derivative, useful as an anti-infective agent, is elaborated.

15 cl, 21 dwg, 2 ex, 2 tbl