FIELD: chemistry.
SUBSTANCE: claimed invention relates to novel co-crystal, containing (rac)-tramadol HCl and celecoxib, with respective molecular ratio 1:1. Co-crystal can be used for treating pain, preferably acute pain, chronic pain, neuropathic pain, noticetive pain, minor and from severe to moderate pain, hyperalgesia, pain, associated with central sensitisation, allodynia or cancer pain, including diabetic neuropathy or diabetic peripheral neuropathy and osteoarthritis, fibromyalgia; rheumatois arthritis, ankylosing spondilitis, glenohumeral periarthritis or ischias. Co-crystal is characterised by peaks of powder X-ray diffraction, obtained with application of copper (CuKα1 1.54060 E), and irradiation and absorption bands of infrared spectra. Co-crystal has orthorhombic elementary cell with the following dimensions: a=11.0323 (7) E,b=18.1095 (12) E,c=17.3206 (12) E, as well as endothermic acute peak, corresponding to melt point, with start at 164°C.
EFFECT: invention also relates to method of obtaining co-crystal and based on it pharmaceutical composition.
8 cl, 9 dwg, 3 tbl, 1 ex
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