FIELD: chemistry.
SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining N,N'-di(1-adamantyl)bispidin-9-ones, where R=R'=methyl (1a), R=R'=ethyl (1b), R=R'=propyl (1c), R=methyl and R'=1-adamantylaminomethyl (2), R=R'=1-adamantylaminomethyl (3). Method is realised by two-stage condensation, at the first stage condensed is 1-aminoadamantane with formaldehyde, at the second stage formed product is condensed with ketones in the same reactor with heating in butanol or other alcohols. Obtained products are extracted after condensing reaction mass under vacuum with hot toluene and re-crystallised from toluene.
EFFECT: N,N'-di(1-adamantyl)bispidin-9-ones, which can be used as substances for medications and as initial substances for obtaining novel derivatives of N,N'-di(1-adamantyl)bispidine 
.
5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| FRAGRANT N,N-DI(TERT-BUTYL)BISPIDIN-9-ONS | 2015 |
|
RU2596821C1 |
| 1,5-BIS[(TERT-BUTYLAMINO)METHYL]-N,N'-DI-TERT-BUTYLBISPIDIN-9-ONE AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2472793C1 |
| NEW BISPIDINE COMPOUNDS USEFUL IN TREATMENT OF CARDIAC ARRHYTHMIAS | 2000 |
|
RU2250903C2 |
| FRAGRANT 3,6-DIAZAHOMOADAMANTAN-9-ONES | 2014 |
|
RU2559051C1 |
| METHOD OF PRODUCING BICYCLIC COMPOUNDS OR STEREOISOMERS OF THE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS WITH ACIDS | 0 |
|
SU1222197A3 |
| N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES WITH PHARMACOLOGICAL EFFECT, PHARMACOLOGICAL COMPOSITIONS ON THEIR BASE, AND APPLICATION METHOD | 2006 |
|
RU2333211C1 |
| ALICYCLIC DERIVATIVES OF N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES, HAVING PHARMACOLOGICAL ACTIVITY, AND MEDICINAL AGENTS ON THEIR BASIS | 2011 |
|
RU2489436C2 |
| N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3.3.1]NONANES, PHARMACEUTICAL COMPOSITIONS BASED THEREON AND USE THEREOF | 2015 |
|
RU2613071C1 |
| 3,7-DIAZABICYCLO[3,3,1]-CONTAINING PREPARATIONS AS ANTI-ARRHYTHMIC COMPOUNDS | 2002 |
|
RU2286993C2 |
| 2′, 2′, 5,7- TETRAMETHYL -6- OXOSPIRO- (1,4- DIAZAADAMANTANE -2,4′- TETRAHYDROPYRWNE) | 1984 |
|
SU1162195A1 |
