FIELD: biotechnologies.
SUBSTANCE: new alicyclic derivatives are described from N,N'-substitute 3,7-diazabicyclo[3.3.1]nonanes of general formula 1
,
where E is carbonyl group; R1 is H, C1-C6 alkyl, C1-C10alkoxy; R2 is fragments of structural formulas (1.1a), (1.3a) or (1.4a), representing biheterocyclic relevant 5-member nuclei, containing N and/or S as heteroatoms, connected to each other by -CH2-(possibly substituted with alkyl), -C(=O)-, -NH-,-NH-CH2-(possibly substituted with alkyl); other R3 - R4 independently mean H, C1-C6 alkyl, C1-C10alkoxy.
EFFECT: compounds have pharmacological activity and may be used for treatment of Alzheimer's disease, Parkinson's disease and other neurodegenerative pathologies.
8 cl, 7 ex, 1 tbl
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| TRICYCLIC DERIVATIVES OF N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES, HAVING PHARMACOLOGICAL ACTIVITY, AND MEDICINAL AGENTS BASED THEREON | 2011 |
|
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