N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES WITH PHARMACOLOGICAL EFFECT, PHARMACOLOGICAL COMPOSITIONS ON THEIR BASE, AND APPLICATION METHOD Russian patent published in 2008 - IPC C07D471/08 A61K31/444 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention concerns new N,N'-substituted 3,7-diazabicyclo[3.3.1]nonanes of the general formula 1: (HY), where HY is hereinafter a pharmacologically acceptable acid; E is , R₁ is H, low-grade alkyl, C₁-C₁₀alkoxy; R₂ is generally represented by the general formulae (1.1a) , (1.2a) , (1.3a) , (1.4a) , where L is CHR₁₁, ; R₁₁ is H, NH₂; R₁₅ is H, low-grade alkyl, C₁-C₁₀alkoxy; R₁₉, R₁₉', R₂₀ and R₂₀' can be equal or different, and each is independently H, low-grade alkyl, C₁- C₁₀alkoxy; R₂₄ and R₂₅ can be equal or different, and each is independently H, low-grade alkyl, C₁- C₁₀alkoxy; R₃ and R₃' can be equal or different, and each is independently H, low-grade alkyl, C₁- C₁₀alkoxy; R₄ and R₄' can be equal or different, and each is independently H, low-grade alkyl, C₁- C₁₀alkoxy; X is a group of the general formula: (CH₂)_m-Z, where m=0, while Z is acetyl, or X is a valence link. Compounds I are capable of AMPA receptor activity modulation and hence can be applied in pharmaceutical compositions.

EFFECT: obtaining compound capable of AMPA receptor activity modulation.

12 cl, 2 dgw, 2 tbl, 11 ex