FIELD: chemistry.
SUBSTANCE: invention relates to field of biotechnology, immunology and genetic engineering. Genetic modification contains deletion of endogenic low-affinity FcγR locus, where contain functional FcRγ-chain. Modified mice express up to five genes of low-affinity human FcγR on antigen-presenting cells of host immune system. Also described is method of screening substance, containing Fc site of human antibody by means of said mice. Invention can be used in the field of medicine.
EFFECT: presented are genetically modified mice, not related to man, and methods and compositions for their obtaining and application.
15 cl, 11 dwg, 6 tbl, 8 ex
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