FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry, particularly to a mouse comprising an endogenous locus α-chain FcγRI promoter α-chain FcγRI and a regulatory sequence operably linked to the gene α-chain FcγRI coding α-chain FcγRI, as well as to a method for its creation. Also disclosed is a mouse embryonic stem cell for producing a mouse which expresses a functional FcγRI protein containing extracellular portion of human α-chain FcγRI and intracellular portion of murine α-chain FcγRI. Invention also relates to a mouse embryo for producing a mouse which expresses functional FcγRI protein containing extracellular portion of human α-chain FcγRI and intracellular portion of mouse α-chain FcγRI.
EFFECT: invention enables to efficiently obtain a mouse which expresses FcγRI protein comprising an extracellular portion of human α-chain FcγRI and intracellular portion of mouse α-chain FcγRI.
24 cl, 32 dwg, 3 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMANIZED T-CELL MEDIATED IMMUNE RESPONSES IN NON-HUMAN ANIMALS | 2016 |
|
RU2732628C2 |
| GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES | 2012 |
|
RU2660564C2 |
| GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MOLECULES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX | 2012 |
|
RU2797549C2 |
| HUMANIZED RODENTS FOR TESTING THERAPEUTIC AGENTS | 2019 |
|
RU2805212C2 |
| HUMANIZED MODEL OF KIDNEY AND LIVER DISORDERS | 2018 |
|
RU2772583C2 |
| ANIMALS CONTAINING HUMANIZED DIPEPTIDYL PEPTIDEASE IV (DPP4) | 2015 |
|
RU2648166C1 |
| HUMANISED IL-15 ANIMALS | 2014 |
|
RU2674910C2 |
| HUMANISED ANIMALS BY C5 AND C3 | 2015 |
|
RU2713327C2 |
| FCγR HUMANISED MICE | 2010 |
|
RU2549695C2 |
| NON-HUMAN ANIMALS HAVING A HUMANIZED B-CELL ACTIVATING FACTOR GENE | 2014 |
|
RU2670016C1 |
