FIELD: biotechnology.
SUBSTANCE: invention relates to a method of using a genetically modified mouse to determine the therapeutic effect of a human antibody, including the introduction of a human mouse antibody. The said mouse contains in its genome an immunoglobulin heavy chain locus that contains an immunoglobulin heavy chain variable region, an immunoglobulin heavy chain constant region containing one or more CH gene segments, wherein the immunoglobulin heavy chain constant region additionally contains: Cγ2 human gene segment, Cγ3 human gene segment, Cμ human or rodent gene segment, Cδ human or rodent gene segment, Cε human or rodent gene segment and/or Cα human or rodent gene segment.
EFFECT: invention is effective for conducting non-clinical testing of complex therapeutic agents.
28 cl, 13 dwg, 14 tbl, 6 ex
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