QUINOLONE ANALOGUES AND RELATED METHODS Russian patent published in 2015 - IPC C07D471/14 C07D513/14 A61K31/4375 A61K31/444 A61K31/4545 A61K31/496 A61K31/497 A61K31/551 A61K31/5377 A61P31/00 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula , wherein A and V independently represents H or a halogen; Q is absent; R⁴ independently represents H, a C1-C6 alkyl or C3-C6 cycloalkyl; R⁷ represents H; and R⁸ represents a C1-C10 alkyl substituted by OH or C1-C6 alkoxy; or C_1-4 alkyl substituted by a 5-6-merous aromatic heterocyclic ring containing 1-2 heteroatoms specified in N and S, wherein the above aromatic heterocyclic ring is optionally substituted by a C1-C10 alkyl; or in -NR⁷R⁸, R⁷ and R⁸ together with N can form an optionally substituted azacyclic ring containing where applicable an additional heteroatom specified in H, O and S, as a cycle member, optionally substituted by a C1-C10 alkyl, which is substituted by a C1-C6 alkoxy; m is equal to 0; n is equal to 0. The invention also refers to a compound of formula (wherein the substitutes are those as specified in the patient claim), to a pharmaceutical composition containing a therapeutically effective amount of the compounds of formula (VIII), and to a method of treating or relieving a cell-proliferative disorder.

EFFECT: compound of formula (VIII) inhibiting cell proliferation or cell apoptosis.

12 cl, 1 dwg, 14 tbl, 55 ex