FIELD: chemistry.
SUBSTANCE: present invention refers to compounds of formula (I) and their pharmaceutically acceptable salts, useful as inhibitors of IRAK-kinase. In formula (I), ring A is pyrazolyl, and the remaining radicals and symbols have values given in the claim.
I.
EFFECT: disclosed are pyridazinone macrocycles as IRAK-kinase inhibitors and use thereof.
9 cl, 1 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MACROCYCLIC COMPOUNDS AS IRAK1/4 INHIBITORS AND USE THEREOF | 2016 |
|
RU2730016C2 |
| HETEROARYL COMPOUNDS AS IRAK TYPE II INHIBITORS AND THEIR USE | 2019 |
|
RU2810338C2 |
| HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USE THEREOF | 2016 |
|
RU2743360C2 |
| MACROCYCLIC PYRIDAZINONE DERIVATIVES | 2014 |
|
RU2660435C2 |
| NOVEL PYRIMIDINIMIDAZOLAMINES AS MODULATORS OF KINASE ACTIVITY | 2015 |
|
RU2690679C2 |
| PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | 2014 |
|
RU2663898C2 |
| PYRUVATEKINASE MODULATORS AND THEIR USE | 2018 |
|
RU2797518C2 |
| HETEROARYL COMPOUNDS AS TKB INHIBITORS AND USE THEREOF | 2015 |
|
RU2742122C2 |
| PYRIDINES, PYRIMIDINES AND PYRAZINES AS BRUTON'S TYROSINE KINASE INHIBITORS AND USE THEREOF | 2014 |
|
RU2712220C2 |
| IMIDAZO[1,2-b]PYRIDAZINE AND PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITOR | 2007 |
|
RU2487875C2 |
