AMIDE DERIVATIVE Russian patent published in 2014 - IPC C07D413/12 C07D413/14 A61K31/4245 A61K31/5377 A61P3/04 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) , where R¹ is a hydrogen atom or a C₁-C₆-alkyl group, substituted with one or two substitutes selected from C₁-C₆-alkoxy group, hydroxyl group, which can be substituted with a C₁-C₆-alkylcarbonyl group (substituted with one or two substitutes γ), and a 4-6-member saturated monocyclic heterocyclic carbonyl group containing a N atom; γ is a hydroxyl group, amino group, di(C₁-C₆-alkyl)amino group and carbamoyl group; R² is a H atom or a C₁-C₆alkyl group, which can be substituted with a hydroxyl group; or R¹ and R², together with the nitrogen atom with which they are bonded, can be combined to form an azetidine group, a pyrrolidine group or morpholine group, which can be substituted with one hydroxyl group or a hydroxy-C₁-C₆-alkyl group; R³ and R⁴ is a C₁-C₆-alkyl group; R⁵ is a halogen atom or a C₁-C₆-alkyl group; R⁶ is a halogen atom; m and n denote an integer from 0 to 1; V and W are CH; X, Y and Z each independently can be CH or N. The invention also relates to a pharmaceutical composition containing a compound of formula (I), use of the compound of formula (I) and a method of treating sugar diabetes a disease associated with diabetes.

EFFECT: compounds of formula (I), having hypoglycemic activity.

21 cl, 6 tbl, 72 ex