FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to maleimide derivatives of fluorine-containing chlorine and its metal complex of general formula I, where at M=2H and M=Zn. Invention also relates to intermediates of formula I, where R=NH2; M=2H (Ic) and R=N3; M=Zn (Id).
EFFECT: technical result: obtained 5,10,15,20-tetrakis (4-N-maleimido-2,3,5,6-tetrafluorophenyl)-17,18-N-methylpyrrolidinochlorine and zinc complex 5,10,15,20-tetrakis(4-N-maleimido-2,3,5,6-tetrafluorophenyl)-17,18-N-methylpyrrolidinochlorine exhibiting antineoplastic activity.
3 cl, 1 tbl, 2 ex
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Authors
Dates
2020-07-07—Published
2019-07-15—Filed