ANTIVIRAL COMPOUNDS AND THEIR APPLICATION Russian patent published in 2015 - IPC C07D401/04 C07D239/54 C07D405/04 C07D409/04 A61K31/506 A61K31/513 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of general formula (I) or their pharmaceutically acceptable salts, which possess properties of RNA-polymerase inhibitor, in particular HCV inhibitor. Such disease can be hepatitis C. In formula (I)

is selected from the group, including simple carbon-carbon bond and double carbon-carbon bond; R¹ represents hydrogen atom; R² represents hydrogen atom; R³ represents hydrogen atom; R⁴ is selected from the group, including

and ,

R⁵ is selected from the group, including hydrogen atom, C₁-C₆alkyl and C₁-C_6alkyloxy; R⁶ is selected from the group, including hydrogen atom, C₁-C₆alkyl and C₁-C₆alkyloxy; R⁷ is selected from the group, including hydrogen atom, phenyl, 5-membered heterocycle, carbocycle with 2 condensed cycles, where 5-membered heterocycle contains at least 1 heteroatom, selected from the group, consisting of N, O and S, and where phenyl, heterocycle and carbocycle with 2 condensed cycles are optionally substituted with at least one of R^J and R^K.

EFFECT: compounds can be used for treatment of disease, which can be treated by HCV inhibition.

21 cl, 2 tbl, 7 ex