N-PHENYL-DIOXOX-HYDROPYRIMIDINE USED AS HEPATITIS C VIRUS INHIBITOR (HCV) Russian patent published in 2015 - IPC C07D239/22 C07D239/54 C07D401/10 C07D403/10 C07D405/10 C07D409/10 C07D413/10 C07D239/553 A61K31/513 A61P31/12 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of structural formula I, their pharmaceutically acceptable salts and crystalline forms, which possess the properties of HCV polymerase inhibitor. In formula I is specified in a group consisting of a single carbon-carbon bond and a double carbon-carbon bond; R¹ represents hydrogen; R² is specified in a group consisting of hydrogen and halo; R³ represents hydrogen; R⁴ is specified in a group consisting of halo, C₁-C₆alkyl, C₁-C₆alkylsulphonyl and 5-6-merous heteroaryl containing heteroatom specified in N, O and S, wherein alkyl is optionally substituted by one or more hydroxy; R⁵ is specified in a group consisting of hygrogen, hydroxy, C₁-C₆alkyloxy and halo; L is specified in a group consisting of C(R^A)=C(R^B), ethylene and cyclopropyl-1,2-ene; R^A and R^B are independently specified in a group consisting of hydrogen, C₁-C₆alkyl, C₁-C₆alkyloxy and halo; R⁶ represents C₆aryl optionally substituted by one or more substitutes independently specified in a group consisting of R^E, R^F, R^G, R^H, R^I and R^J; the substitutes R^E, R^F, R^G, R^H, R^I and R^J are presented in the patent claim.

EFFECT: invention refers to the pharmaceutical composition containing the above compounds, to using the compounds for inhibiting HCV RNA-polymerase and treating hepatitis C and to a method of preparing the above compounds.

40 cl, 23 dwg, 7 tbl, 40 ex