AMINOPYRAZOL TRIAZOLOTHIADIAZOLE C-MET PROTEIN KINASE INHIBITORS Russian patent published in 2015 - IPC C07D513/04 A61K31/4709 A61K31/429 A61P35/00

Abstract RU 2552993 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula , wherein R¹ represents methyl or ethyl, R² represents hydrogen, fluorine or methyl, R³ represents hydrogen, fluorine or methyl, each R⁴ represents hydrogen and R⁵ represents hydrogen, methyl. The invention also refers to a pharmaceutical composition for treating or relieving a degree of severity of a proliferative disorder by means of compounds of formula (I).

EFFECT: compounds are effective in preparing a drug for treating or reducing a degree of severity of metastatic cancer, glioblastoma, gastric carcinoma or cancer specified in colon cancer, breast cancer, prostate cancer, cerebral cancer, liver cancer, pancreatic cancer or lung cancer and hepatocellular carcinoma.

16 cl, 4 tbl, 6 ex

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RU 2 552 993 C2

Authors

Lauffer Dehvid

Li Pan'

Makginti Kira

Dates

2015-06-10—Published

2010-05-27—Filed