METHOD FOR ASSESSING ABSORPTION FUNCTION OF SMALL INTESTINE Russian patent published in 2015 - IPC A61B6/03 A61K51/00 A61M25/01 

FIELD: medicine.

SUBSTANCE: method involves the nasoenteric administration of ^99mTc-pertechnetate into a small intestine at 1.0-14 MBq/kg diluted with normal saline to an amount of 20 ml. That is immediately followed by a dynamic scintigraphy by means of two-detector rotation gamma-chamber for 60 minutes with a gamma-chamber detection mounted above a projection of the intestine and liver. Following the examination results enables calculated an absorption coefficient of a radiopharmaceutical agent (K); thereafter the scintigraphy is continued in the mode of "The Whole Body", which provides a basis to determine a percentage of the radiopharmaceutical agent (A) absorbed from an intestinal lumen. If the absorption coefficient is less than 3 and the absorption is less than 50% from the administered radiopharmaceutical agent, the small intestinal malabsorption is stated. K is described by the scintigram forming the sharpest image of the liver and having an area of interest 100 pxls to be marked within a liver, which is followed by constructing an activity/time curve. K is calculated as a slope of the curve to a horizontal axis with using the first 4 minutes of the linear rise of the curve by formula: K=(y₂-y₁)/(t₂-t₁)×60, wherein K is the absorption coefficient, t₁ and t₂ are time distances, seconds; y₁ is a pulse count within the time distance t₁, y₂ is a pulse count within the time distance t₂. To calculate A, an area including the whole patient's body and an area covering the visualised enteric loops are marked on the scintigram. The calculation follows the formula: A=(n(b)-n(e))/n(e)×100%, wherein n(b) is the total pulse count recorded within the whole body; n(e) is the total pulse count recorded within the small intestine.

EFFECT: method provides the high information value of the examination ensured by the complex analysis of the enteric function parameters in the early postoperative period.

3 cl, 3 dwg, 1 ex