METHOD OF SYNTHESISING E1-ACTIVATING ENZYME INHIBITORS Russian patent published in 2015 - IPC C07D487/04 C07C215/44 C07C217/52 C07C219/24 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining a formula compound. The method includes a stage of binding a formula compound with a formula compound in the presence of a base with the formation of the formula (I) compound. In formula (I) stereochemical configurations in the positions, marked with asterisks, are relative; R^b represents hydrogen; R⁰⁰ represents a C_1-10 aliphatic group or a C_6-14 aryl group, including one-three rings; R^d, R^e, R^e', R^f, R^h, R^h', R^k represent hydrogen; R^g represents chlorine, fluorine, iodine or bromine; R^m represents a protective hydroxyl group; values of radicals R^a, R*, R^c are given in the invention formula. In formulas (II) and (III) R^a, R^b, R^c, R^d, R^e, R^e', R^f, R^g, R^h, R^h', R^j, R^k and R^m are such as determined in formula (I) and R¹ represents -CH₂CHO. The invention also relates to methods of obtaining compounds of formulae (V), (VI), (VId) and to a compound of the structural formula (IIa). Structural formulae of compounds (V), (VI), (VId), (IIa) are given in the invention formula.

EFFECT: method makes it possible to carry out synthesis in a regioselective way and use the obtained product without purification.

15 cl, 1 tbl, 26 ex