Show metadata Hide metadata

(19)

(11)

2 557 554

(13)

(51)

IPC

C07H19/23(2006-01-01)

A61K31/7056(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2014136547/04, 2014-09-09

(24)

Start date

2014-09-09

(22)

Actual filing date

2014-09-09

(45)

Published

2015-07-27

(72)

Inventor

Vartanjan Amalija ArtashevnaBaryshnikova Marija Anatol'EvnaEremina Vera AleksandrovnaMiniker Tat'Jana DavidovnaTikhonova Nadezhda IvanovnaKuz'Mina Natal'Ja Evgen'EvnaEhktova Lidija Vladimirovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Onkologicheskij Nauchnyj Tsentr Imeni N.N. Blokhina" Rossijskoj Akademii Meditsinskikh Nauk Im. N.N. Blokhina" Ramn)

INDOLOCARBAZOLE DERIVATIVE BLOCKING TUMOUR VASCULOGENIC MIMICRY Russian patent published in 2015 - IPC C07H19/23 A61K31/7056 A61P35/00

Abstract RU 2557554 C1

FIELD: medicine.

SUBSTANCE: invention refers to indolocarbazole derivatives blocking tumour vasculogenic mimicry and applicable in medicine, of general formula I: , wherein Gly is pentose and hexose residues, R represents an amino group of 6-amino-12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; a formamido group of 6-formamido-12-(β-D-xylopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; an oxylethylamino group of 6-(2-oxyethyl)amino-12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; a cyanoethylamino group of 6-(2-cyanoethyl)amino-12-(β-D-xylopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione and 6-(2-cyanoethyl)amino-12-(β-D-galactopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione; a picolinamido group of 6-picolinamido-12-(β-D-xylopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione.

EFFECT: there are presented new compounds with the cytotoxic and antiangiogenic properties active with respect to HCT-116 colon cancer and Mel Kor melanoma.

6 ex, 1 tbl, 3 dwg

Similar patents RU2557554C1

Title	Year	Author	Number
N-GLYCOSIDES OF INDOLO[2,3-a]PYRROLO[3,4-c]CARBAZOLES HAVING ANTITUMOUR ACTIVITY	2014	Borisova Larisa Mikhajlovna Golubeva Irina Sergeevna Gorjunova Ol'Ga Vasil'Evna Eremina Vera Aleksandrovna Zhukova Ol'Ga Stepanovna Kiseleva Marina Petrovna Markova Nadja Petkova Medvedeva Lidija Aleksandrovna Mel'Nik Stalina Jakovlevna Miniker Tat'Jana Davydovna Smirnova Zoja Sergeevna Tikhonova Nadezhda Ivanovna Fetisova Larisa Vladimirovna Ehktova Lidija Vladimirovna Jartseva Irina Vjacheslavovna	RU2548045C1
DERIVATIVE OF THE CLASS OF N-GLYCOSIDES INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE - N-{12-(β-D-XYLOPYRANOSYL)-5,7-DIOXO-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOL-6-YL} PYRIDINE-2-CARBOXAMIDE, WHICH HAS CYTOTOXIC AND ANTITUMOR ACTIVITY	2017	Golubeva Irina Sergeevna Eremina Vera Aleksandrovna Moiseeva Natalya Ivanovna Ektova Lidiya Vladimirovna Yavorskaya Nadezhda Petrovna	RU2667906C1
ANTITUMOUR AGENT	2014	Lantsova Anna Vladimirovna Oborotova Natalija Aleksandrovna Orlova Ol'Ga L'Vovna Polozkova Alevtina Pavlovna Shprakh Zoja Sergeevna Sanarova Ekaterina Viktorovna Smirnova Zoja Sergeevna Kiseleva Marina Petrovna Borisova Larisa Mikhajlovna Ignat'Eva Elena Vladimirovna Guljakin Il'Ja Dmitrievich	RU2572691C1
METHOD OF PRODUCING INDOLO[2,3]PYRROLO[3,4-c]CARBAZOLE-5,7-DIONES N-GLYCOSIDES EXHIBITING CYTOTOXIC AND ANTICANCER ACTIVITY	2009	Mel'Nik Stalina Jakovlevna Vlasenkova Natal'Ja Kirillovna Garaeva Ljudmila Davidovna Golubeva Irina Sergeevna Gorjunova Ol'Ga Vasil'Evna Eremina Vera Aleksandrovna Markova Nadja Petkova Miniker Tat'Jana Davidovna Plikhtjak Irina Leonidovna Tikhonova Nadezhda Ivanovna Ehktova Lidija Vladimirovna Jartseva Irina Vjacheslavovna	RU2427585C9
TUMOUR THERAPY AGENT	2019	Dmitrieva Mariya Vyacheslavovna Borisova Larisa Mikhajlovna Kiseleva Marina Petrovna Golubeva Irina Sergeevna Ektova Lidiya Vladimirovna Eremina Vera Aleksandrovna Tikhonova Nadezhda Ivanovna Orlova Olga Lvovna Nikolaeva Lyudmila Leonidovna Shprakh Zoya Sergeevna Lantsova Anna Vladimirovna Gusev Dmitrij Vasilevich Ignateva Elena Vladimirovna Oborotova Nataliya Aleksandrovna Kulbachevskaya Nataliya Yurevna Konyaeva Olga Ivanovna Ermakova Nadezhda Pavlovna	RU2726801C1
DERIVATIVES OF GLYCOSIDES OF INDOLO[2,3-A]-PYRROLO[3,4-C]CARBAZOL-5,7-DIONES ELICITING CYTOTOXIC AND ANTITUMOR ACTIVITY	2003	Mel'Nik S.Ja. Ostrovskaja L.A. Adanin V.M. Bakhmedova A.A. Bljukhterova N.V. Vlasenkova N.K. Garaeva L.D. Gorjunova O.V. Miniker T.D. Plikhtjak I.L. Rykova V.A. Fomina M.M. Ehktova L.V. Jartseva I.V.	RU2255089C1
ANTI-CANCER DRUG TOPOISOMERASE I INHIBITOR	2022	Lantsova Anna Vladimirovna Nikolaeva Lyudmila Leonidovna Orlova Olga Lvovna Smirnova Galina Borisovna Pokrovskij Vadim Sergeevich Sanarova Ekaterina Viktorovna Polozkova Alevtina Pavlovna Shprakh Zoya Sergeevna Ignateva Elena Vladimirovna Borisova Larisa Mikhajlovna Kiseleva Marina Petrovna Dmitrieva Mariya Vyacheslavovna Golubeva Irina Sergeevna Kulbachevskaya Nataliya Yurevna Konyaeva Olga Ivanovna Ermakova Nadezhda Pavlovna Prosalkova Irina Robertovna Gusev Dmitrij Vasilevich Eremina Vera Aleksandrovna Pugacheva Ruzhena Borisovna	RU2786727C1
METHOD FOR TREATMENT OF SW620 HUMAN COLON CANCER IN EXPERIMENT	2017	Smirnova Galina Borisovna Borisova Yuliya Aleksandrovna Shprakh Zoya Sergeevna Treshchalina Elena Mikhajlovna	RU2665168C1
METHOD FOR PRODUCING AMINO ACID ANALOGUES OF THE ANTITUMOUR ANTIBIOTIC REBECCAMYCIN	2020	Goryunova Olga Vasilevna Mironova Mariya Vladimirovna Golubeva Irina Sergeevna	RU2755572C1
INDOLOPYRROLOCARBAZOLE DERIVATIVES OF SUGARS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF INHIBITION OF TUMOR PROLIFERATION	1997	Sauln'Er Mark Georg Behlasubraman'Jan Nilakantan Frennesson Dehvid Bertil St. Loran Denis R. Lehngli Dehvid R.	RU2167880C2

RU 2 557 554 C1

Authors

Vartanjan Amalija Artashevna

Baryshnikova Marija Anatol'Evna

Eremina Vera Aleksandrovna

Miniker Tat'Jana Davidovna

Tikhonova Nadezhda Ivanovna

Kuz'Mina Natal'Ja Evgen'Evna

Ehktova Lidija Vladimirovna

Dates

2015-07-27—Published

2014-09-09—Filed