METHOD OF PREDICTING RISK OF PRIMARY OPEN-ANGLE GLAUCOMA DEVELOPMENT Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: peripheral venous blood is sampled, DNA from the blood is isolated and the analysis of polymorphisms of gens TNFR2 (+1663A/G TNFR2) is performed. Values y1 and y2 are determined by formulae of a linear discriminant function with taking into account the patients' age, presence of the cardio-vascular system pathology, systolic and diastolic arterial pressure, presence of primary open-angle glaucoma (POAG) in relatives, presence of the accompanying eye pathology, micro-vascular disorders in the front section of the eye and the state of a pigment rim of the papillary edge of the iris, presence of a degree of the front angle chamber pigmentation and genetic version by locus +1663A/G TNFR2. A risk to form primary open-angle glaucoma is predicted in case if y2 is larger than y1. The claimed method makes it possible to predict POAG development basing on data about genetic polymorphism +1663A/G TNFR2 in a combination with other predictors of glaucoma development. The invention can by applied for obtaining criteria for the evaluation of the risk of POAG development in inhabitants of the Central Chernozem (Black Soil) Region of Russia of Russian nationality to form a group with an increased risk of POAG development.

EFFECT: increase of prediction accuracy.

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