FIELD: medicine.
SUBSTANCE: claimed invention relates to field of biotechnology. Claimed are: therapeutic antibody and therapeutic antibody fragment for increasing production of platelets, including thrombopoetin (TPO) mimetic peptide, which contains sequence IEGPTLRQWLAARA, and inserted as addition to C-terminus of constant region of light chain and/or in position of less than 20 amino acids following C-terminus of hinge region of heavy chain. In addition, described are composition, containing antibody or its therapeutically active fragment, and method of increasing production of platelets in individual, including introduction of said composition, as well as nucleic acid, coding antibody polypeptide, containing TPO mimetic polypeptide.
EFFECT: invention enables higher and faster production of platelets in comparison with knows structures of antibody, where mimetic peptide is inserted instead of one of CDR.
13 cl, 4 dwg, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES AGAINST ANGPTL3/8 COMPLEX AND METHODS OF THEIR USE | 2019 |
|
RU2799796C2 |
| METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES | 2010 |
|
RU2585488C2 |
| ANTIBODIES CAPABLE OF BINDING TO HUMAN CANNABINOID RECEPTOR 1 (CB1) | 2016 |
|
RU2727018C1 |
| ANGIOPOIETIN-2-SPECIFIC COUPLING AGENTS | 2005 |
|
RU2404992C2 |
| STRUCTURES AIMED AT AFP/MHC PEPTIDE COMPLEXES AND TYPES OF THEIR USE | 2016 |
|
RU2754041C2 |
| ANTIBODIES TARGETING BONE | 2018 |
|
RU2801206C2 |
| ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS FOR USING THEM | 2008 |
|
RU2511410C2 |
| SINGLE LINKER ANTIBODIES FabFv AND METHODS FOR PRODUCING THEREOF | 2013 |
|
RU2714159C2 |
| METHODS OF TREATING CANCER USING ANTAGONISTS BINDING TO COMPONENTS OF THE SIGNAL PATH PD-1, AND TAXANES | 2014 |
|
RU2719487C2 |
| METHODS OF INHIBITING OCULAR ANGIOGENESIS | 2009 |
|
RU2530583C2 |
