STRUCTURES AIMED AT AFP/MHC PEPTIDE COMPLEXES AND TYPES OF THEIR USE Russian patent published in 2021 - IPC C07K14/705 C07K16/28 A61K39/395 A61P1/16 A61P15/00 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a selected structure to AMC, which specifically binds to a complex containing alpha-fetoprotein (AFP) peptide and a protein of a main histocompatibility complex (MHC) of the I class with Kd approximately from 0.1 pM to approximately 500 pM, to a composition containing it, as well as to a nucleic acid encoding it, and to a cell expressing it. A selected antibody to AMC or its antigen-binding fragment, which specifically binds to a complex containing alpha-fetoprotein (AFP) peptide and a protein of a main histocompatibility complex (MHC) of the I class, a composition containing it, as well as a nucleic acid encoding it, and a cell expressing it are also disclosed. The invention also relates to a method for detecting a cell presenting a complex containing AFP peptide and MHC protein of I class on its surface, as well as to a method for determining, whether an individual suffers from AFP-positive disease, using the above-mentioned structure.

EFFECT: invention allows for effective treatment of an individual suffering from AFP-positive disease.

31 cl, 26 dwg, 10 tbl, 9 ex