PRION-FREE COMPOSITIONS BASED ON NANOPARTICLES AND METHODS OF OBTAINING THEREOF Russian patent published in 2015 - IPC A61K38/38 A61P35/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relate to medicine and deal with pharmaceutical composition for treating cancer, containing nanoparticles, which include albumin, and in fact water-insoluble pharmacologically active anti-cancer agent, prepared from mixture, containing organic phase, which contains in fact water-insoluble pharmacologically acitive anti-cancer agent and albumin solution, subjected to impact of high shear, where prion protein is in fact absent in said composition. Group of inventions also relate to method of obtaining pharmaceutical composition, which contains nanoparticles, including albumin and in fact water-insoluble pharmacologically active agent; method of removing prion protein from pharmaceutical composition, suspected of prion protein presence.

EFFECT: group of inventions provide absence of adverse impact on physical and/or chemical properties of nanoparticles when prion protein is removed by impact of high shear/ligand.

19 cl, 6 ex, 9 dwg, 20 tbl