FIELD: biotechnology.
SUBSTANCE: invention relates to producing a mutant soluble polypeptide of the extracellular domain of the activin IIB (ActRIIB-ECD) receptor, and can be used in medicine.
EFFECT: mutant ActRIIB-ECD polypeptide is capable of binding to myostatin and activin A, but demonstrates reduced affinity binding to bone morphogenetic protein 9 (BMP9) relative to ActRIIB-ECD wild-type polypeptide and can be used for effective treatment of diseases associated with muscular atrophy or diseases of bone system.
19 cl, 12 dwg, 8 tbl, 8 ex
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