METHODS FOR SYNTHESIS OF DIHYDROPYRIDOPHTHALAZINONE DERIVATIVES Russian patent published in 2015 - IPC C07D487/04 C07D249/08 C07D403/04 C07D403/06 

Abstract RU 2561732 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a compound of formula and a salt thereof, which includes reacting a compound of formula or a salt thereof with a hydrazine monohydrate, where R is C1-C6 alkyl; where the compound of formula (5) or a salt thereof is obtained by reacting a compound of formula or a salt thereof with 4-fluorobenzaldehyde in the presence of a reducing agent and an acid or a Lewis acid, where R is C1-C6 alkyl. The invention also relates to alternative methods of producing a compound of formula (1) and to intermediate compounds whose structural formulae are given in the claim.

EFFECT: obtaining a compound of formula (1) using novel methods with improved output and obtaining novel intermediate compounds.

47 cl, 14 ex

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RU 2 561 732 C2

Authors

Van Bin

Chu Dehniehl

Lju Junbo

Tszjan Tsjuan'

Lju Lej

Dates

2015-09-10Published

2011-02-08Filed