FIELD: biotechnologies.
SUBSTANCE: invention describes the hybrid protein based on mutant recombinant L-asparaginase of bacteria Wolinella succinogenes with lowered glutaminase activity and increased resistance to effect of trypsin linked with N-end amino-acid sequence heparin-binding peptide. The invention relates also to strains-producers and to the method of producing of this hybrid protein.
EFFECT: invention allows to expand the range of hybrid proteins based on asparaginase with anticancer activity.
4 cl, 2 dwg, 2 tbl, 27 ex
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