METHOD OF PRODUCING HAEMOSTATIC AGENT BASED ON OXIDISED CELLULOSE USING MICROWAVE ACTION (VERSIONS) Russian patent published in 2015 - IPC C08B15/04 C08B15/02 A61L15/42 A61P7/04 

FIELD: chemistry.

SUBSTANCE: invention provides two versions of a method of producing a haemostatic agent based on oxidised cellulose under the effect of microwave radiation. Version 1 is carried out as follows: oxidising a medical gauze with nitrogen dioxide solution in an inert solvent, the oxidation being carried out under the effect of 70-100 W microwave radiation for 4-5 hours at 40-50°C, wherein the vessel is constantly cooled with an external air current; the solution is then removed in a vacuum created by a water-jet pump; the oxidised tissue is washed and dried. Version 2 is carried out as follows: oxidising powdered cellulose with nitrogen dioxide solution in an inert solvent, the oxidation being carried out under the effect of 60-100 W microwave radiation for 1-5 hours at 40-50°C while stirring, wherein the reaction vessel is constantly cooled with an external air current; the solution is then decanted removed in a vacuum created by a water-jet pump; the oxidised powdered cellulose is then washed and dried.

EFFECT: faster cellulose oxidation and, as a result, the process of producing a haemostatic agent based on oxidised cellulose, obtaining oxidised cellulose with high content of carboxyl groups.

13 cl, 3 tbl