METHOD FOR PRODUCING SMALL-DIAMETER LOW-POROSITY VASCULAR PROSTHESES (VERSIONS) Russian patent published in 2016 - IPC A61L27/58 A61L33/06 A61F2/06 

FIELD: medicine.

SUBSTANCE: what is described is a method, which involves dissolving initial synthetic polymer and protein in hexafluorisopropanol, mixing the polymer solution and the protein solution in polymer: protein ratio (7-9):(1-3); according to the first version, at the first stage of electrospinning, a collection electrode is coated with the prepared composition in an amount of 1.0-10.0% of the required volume; a formed inner layer of the prosthesis is impregnated with the protein solution in the concentration of 1.0-5.0%; at the second stage, the formed inner layer is coated with leftover 90-99% of the composition, and an outer layer of the prosthesis is formed. According to the second version of the method, the formed inner layer of the prosthesis making 0.1-90.0% of a pre-set thickness of a prosthesis wall is coated with the composition containing a mix of polymer and protein in polymer: protein ratio (1-3):(1-7), and an intermediate layer making 0.1-10.0% of the pre-set thickness of the prosthesis wall is formed; it is coated with the leftover amount of the composition to form an outer layer of the prosthesis making 9.0-98.9% of the pre-set thickness of the prosthesis wall; different polymers may be used to form the outer and inner layers of the prosthesis.

EFFECT: producing small-diameter low-porosity vascular prostheses, improving their strength and flexibility characteristics, as well as bio- and haemocompatibility of the vascular prostheses.

4 cl, 2 dwg, 7 ex