FIELD: pharmacology.
SUBSTANCE: invention relates to selective inhibitors of the enzyme of cyclooxygenase-2 (COX-2) of the class of substituted 3(2H) -furanones of the general formula 
and 
and substituted phenanthro[9,10-b]furan-3(2H)-ones of the general formula
, as well as a pharmaceutical composition based thereon. These compounds are effective selective inhibitors of cyclooxygenase-2 (IC50 to 0.004 μg ml, SI to 690).
EFFECT: treatment of chronic forms of arthritis, migraine, trauma, skin diseases, inhibition of angiogenesis and inhibition of cell growth in certain cancers such as neuroblastoma, breast, stomach, lung and large intestine cancers.
15 cl, 4 tbl, 9 ex, 14 dwg
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