PHARMACEUTICAL COMPOSITION FOR LOCAL APPLICATION ON SURFACE OF EPITHELIUM BARRIER, CONTAINING ANTIBODIES PERMEATING THROUGH THIS BARRIER Russian patent published in 2015 - IPC A61K39/395 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns a pharmaceutical composition for local application on the surface of an epithelium barrier, containing a soluble, antigen-binding polypeptide, and a pharmaceutically acceptable carrier, a diluent, or an excipient. The above polypeptide is able to permeate through at least one or more epithelium barriers for less than 8 hours in the absence of a permeation enhancer. The antigen-binding polypeptide as a part of the above pharmaceutical composition represents a single-chain antibody containing the sequence SEQ.ID: 12, SEQ.ID: 13, SEQ.ID: 18, SEQ.ID: 19, SEQ.ID: 20 or SEQ.ID: 21.

EFFECT: using the invention has many advantages as compared to injections and other modes of administration: ease of delivery, as well as reducing or eliminating problems of the patient's compliance with the treatment regimen and sequence accompanying injection delivery.

21 cl, 28 dwg, 3 tbl, 10 ex