CONJUGATES OF FATTY ACIDS AND NIACIN AND APPLICATION THEREOF Russian patent published in 2015 - IPC A61K31/455 C07D213/82 A61P3/00 

Abstract RU 2569063 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to formula I compound:

or its pharmaceutically acceptable salt, or stereoisomer; where each of R1, R2 and R3 is independently selected from the group, consisting of -H, -D, -CI, -F and -C1-C3alkyl; each of W1 and W2 represents NR, or W1 and W2 together can form imidazolidine or piperazine group; each a, b, c and d independently represent -H, -D, -CH3 or -C(O)OR, or two of a, b, c and d, together with single carbon atom, which they are bound to, can form cycloalkyl; each n, o, p and q independently equals 0 or 1; each L independently represent -O-,-S-,-S-S-,

or

m equals 0 or 1; each R6 independently represents H or C1-C6alkyl; each R7 independently represents H or non-branched or branched C1-C10alkyl; each Z independently represents

or

each r independently equals 2, 3 or 7; each s independently equals 3, 5 or 6; t equals 1; each v independently equals 1 or 2; each of R4 and R5 independently represents hydrogen, deuterium or -C1-C4alkyl; and each R independently represents -H or -C1-C3alkyl.

EFFECT: compounds can be used for treatment or prevention of metabolic disorder.

38 cl, 13 ex

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RU 2 569 063 C2

Authors

Miln Dzhill K.

Dzhirousek Majkl R.

Bemis Dzhin Eh.

Vu Chi B.

Dates

2015-11-20Published

2010-08-31Filed