CONJUGATED LIPID DERIVATIVES Russian patent published in 2013 - IPC C07C33/02 C07C43/178 C07C57/03 C07C59/60 C07C69/587 A61K31/45 A61K31/202 A61K31/232 A61P1/16 A61P29/00 A61P3/04 A61P3/06 A61P3/10 A61P43/00 A61P5/50 A61K31/185 A61K31/21 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a new lipid compound of general formula , wherein n=0; R₁ and R₂ are identical or different, and may be specified in a group of substitutes consisting of a hydrogen atom, a C₁-C₇alkyl group, a halogen atom and a C₁-C₇alkoxy group; X represents COR₃ or CH₂OR₄, wherein R₃ is specified in a group consisting of hydrogen, hydroxy, C₁-C₇alkoxy and amino; and R₄ is specified in a group consisting of hydrogen, C₁-C₇alkyl or C₁-C₇acyl, Y represents C₉-C₂₁ alkene with one or more double bonds in E- or Z-configurations with the chain Y being unsubstituted and containing a double bond in the ω-3 position; provided R₁ and R₂ cannot simultaneously represent a hydrogen atom.

EFFECT: invention refers to pharmaceutical compositions containing the lipid compounds which are used for treating and/or preventing the conditions related to high NFkB functions, treating and/or preventing an inflammatory disease or a condition, lower plasma insulin and/or blood glucose levels, treating insulin resistance, treating and/or preventing peripheral tissue insulin resistance and/or diabetic condition, eg type 2 diabetes mellitus.

45 cl, 1 tbl, 1 dwg, 31 ex