PLASMALOGEN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF TREATING AGE-RELATED DISEASES Russian patent published in 2015 - IPC C07D339/04 C07C227/02 C07C229/22 C07C319/02 C07C323/59 C07C323/52 C07C41/18 C07C43/23 A61K31/205 A61K31/385 A61P25/00 A61P25/16 A61P25/28 A61P27/02 A61P3/06 A61P35/00 A61P9/00 A61P9/10 

Abstract RU 2546108 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula I, wherein R1 and R2 are identical or different and specified in an alkyl or alkenyl hydrocarbon chain; the R3 group values split by lipase are specified in the patient claim. R4 and R5 are independently hydrogen or C1-C7alkyl; R6 represents hydrogen or C1-C7alkyl; and R7 and R8 are independently hydrogen or C1-C7alkyl. The invention also refers to using compounds of formulas ,

which are introduced into the mammalian biological system and increase the cell concentrations of specific sn-2 substituted ethanolamine-plasmalogens.

EFFECT: compounds are applicable in treating or preventing the age-related disorders associated with high membrane cholesterol, high amyloids and low plasmalogens, such as neurodegeneration, cognitive disorder, dementia, cancer, osteoporosis, bipolar disorder and vascular diseases.

11 cl, 18 dwg, 7 ex

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RU 2 546 108 C2

Authors

Khan M. Amin

Vud Pol L.

Gudenau Dajan

Mankidi Rishikesh

Akhajjakhonu Pirson

Dates

2015-04-10Published

2009-12-18Filed