FIELD: chemistry.
SUBSTANCE: invention relates to pyrazoline dione derivative of formula
,
as well as to its pharmaceutically acceptable salt, where R1 is selected from hydrogen; possibly substituted C1-C6alkyl; possibly substituted phenyl; possibly substituted C1-C6alkylphenyl; possibly substituted phenylC1-C6alkyl; possibly substituted pyridyl; possibly substituted C1-C6alkylpyridyl; and possibly substituted pyridylC1-C6alkyl; R2 is hydrogen; R3 is hydrogen; R4, R5, R6 and R7 are hydrogen; R8, R9, R10 and R11 are independently selected from hydrogen atoms and C1-C6alkyls; R12 is selected from hydrogen; -CHR17R18; possibly substituted C1-C6alkoxy-carbonyl, possibly substituted -C(O)-phenyl; possibly substituted C1-C6alkylphenyl; possibly substituted phenylC1-C6alkyl, possibly substituted C1-C6alkylheteroaryl or possibly substituted heteroarylC1-C6alkyl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl; R17 and R18 are independently selected from hydrogen; possibly substituted phenyl; possibly substituted heteroaryl, where heteroaryl is selected from pyridyl, pyrrolyl, pyrimidinyl, furyl, imidazolyl, oxazolyl, isoxazolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,5-oxadiazolyl, 1,3,4-oxadiazolyl, 1,3,4-triazinyl and 1,2,3-triazinyl; X is selected from O, NR12, S and S(O)2; n is integer number, selected from 0 and 1; with term "substituted" meaning that said group is substituted with 1-5 substituents, selected from "C1-C6alkyl", "C1-C6alkoxy" and "halogens". Invention also relates to pharmaceutical composition, based on formula (I) compound, intermediate compound of formula
,
method of obtaining formula (I) and (II) compounds.
EFFECT: novel pyrazoline dione derivatives, useful for inhibition of activity or function of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH-oxidase), have been obtained.
17 cl, 2 tbl, 23 ex
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