Patenton — panteon of patents

(19)

RU

(11)

2 230 062

(13)

C2

(51)

IPC

(21) (22)

Application

2001118265/04, 1999-12-21

(24)

Start date

1999-12-21

(22)

Actual filing date

1999-12-21

(45)

Published

2004-06-10

(72)

Inventor

Radzhkhavan Krishnasvami S.Mehlloi Timoti M.Vehria Sehjlesh A.

(73)

Holder

Bristol-Maers Skvibb Ko.

COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR, COMPOSITION OF RAS-FARNESYLT RANSFERASE INHIBITOR, PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

Abstract RU 2230062 C2

FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention relates to complex of ras-farnesyltransferase inhibitor formed by ras-farnesyltransferase inhibitor or its pharmaceutically acceptable salt of the formula: wherein n = 0 or 1; R1 means phenyl; R2 means aralkyl; R3 means heterocyclyl; Z1 means SO2 or 7-β-cyclodextrin or 2-hydroxypropyl-β-cyclodextrin sulfobutyl ether. Complex displays suddenly high water-solubility of inhibitor of ras-farnesyltransferase and can be used for its intravenous administration to cancer patient. Also, invention describes method for preparing this complex. Inhibitors of ras-farnesyltransferase are useful as anti-tumor agents. EFFECT: improved preparing method, valuable medicinal properties of complex. 9 cl, 1 dwg, 4 ex

Similar patents RU2230062C2

Title Year Author Number
DERIVATIVES OF IMIDAZOLE 1997
  • Ding Charl'Z Z.
  • Khant Dzhon T.
  • Kim Sung-Khun
  • Mitt Tumas
  • Bkhide Radzhiv
  • Lefteris Katerina
 RU2225405C2
SYNERGIC METHODS AND COMPOSITIONS FOR CANCER TREATMENT 2001
  • Li Frehnsis I.
 RU2264217C2
COMPOSITION OF BCL-2 INHIBITOR BASED ON CYCLODEXTRIN 2019
  • Shman Karolina
  • Chan Tkhyu Tkhyui
  • Pean Zhan-Manyuel
  • Shanrion Majya
 RU2804366C2
INHALATION COMPOSITION CONTAINING SULFOALKYL ETHER 2004
  • Pipkin Dzhejms D.
  • Tsimmerer Rupert O.
  • Tompson Dajan O.
  • Mosher Dzherol'D L.
 RU2388462C2
PREPARATION COMPRISING INHIBITOR OF HETEROTRIMERIC G PROTEINS SIGNAL TRANSDUCTION IN COMBINATION WITH OTHER CYTOSTATIC AGENT FOR THERAPEUTIC USING IN CANCER TREATMENT 2000
  • Prevo Greguar
  • Lonsham Mari-Odil'
  • Gordon Tomas
  • Morgan Barri
 RU2298417C2
DERIVATIVES OF IMIDAZOLE, PHARMACEUTICAL COMPOSITION, AND METHODS FOR INHIBITION OF ACTIVITY OF FARNESYL PROTEIN TRANSFERASE AND PRENYLTRANS- FERASE AND SUPPRESSION OF TUMOR GROWTH 1998
  • Bkhajd Radzhiv S.
  • Ding Charlz Z.
  • Khant Dzhon T.
  • Kim Sung-Khun
  • Lefteris Katrina
 RU2211838C2
DERIVATIVES OF IMIDAZOLE AS INHIBITORS OF PRENYL TRANSFERASE, PHARMACEUTICAL COMPOSITION AND METHODS FOR TREATMENT BASED ON THEREOF 1999
  • Gordon Tomas D.
  • Morgan Barri A.
 RU2241712C9
INHALATION FORMULATION CONTAINING SULFOALKYL ETHER GAMMA-CYCLODEXTRIN AND CORTICOSTEROID 2004
  • Pipkin Dzhejms D.
  • Tsimmerer Rupert O.
  • Tompson Dajan O.
  • Mosher Dzherol'D L.
 RU2390330C2
AQUEOUS PHARMACEUTICAL COMPOSITIONS BASED ON 1,2-DIHYDROPYRIDINE COMPOUNDS 2019
  • Hird, Geoffrey S.
  • Bommareddy, Ganesh S.P.
  • Joshi, Anjali
  • Mcshane, James
 RU2824582C2
CAPSULES CONTAINING WATER FILLING COMPOSITIONS, STABILISED WITH DERIVATIVE OF CYCLODEXTRIN 2003
  • Tompson Dajan O.
  • Zimmerer Rupert O.
  • Pipkin Dzhejms D.
 RU2359698C2

RU 2 230 062 C2

Authors

Radzhkhavan Krishnasvami S.

Mehlloi Timoti M.

Vehria Sehjlesh A.

Dates

2004-06-10—Published

1999-12-21—Filed

download Download PDF read Similar patents